http://www.kulan.cz/index.php?action=history&feed=atom&title=Dyslipidemie 2026-05-05T15:41:57Z Historie editací této stránky MediaWiki 1.15.1 http://www.kulan.cz/index.php?title=Dyslipidemie&diff=9237&oldid=prev 2023-10-28T14:10:46Z

<p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr valign='top'> <td colspan='2' style="background-color: white; color:black;">← Starší verze</td> <td colspan='2' style="background-color: white; color:black;">Verze z 28. 10. 2023, 14:10</td> </tr> <tr><td colspan="2" class="diff-lineno">Řádka 301:</td> <td colspan="2" class="diff-lineno">Řádka 301:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[[category:Metabolismus]]</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[[category:Metabolismus]]</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[[category:Farmakologie]]</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[[category:Farmakologie]]</div></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>[[category:Gastroenterologie]]</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>[[category:Gastroenterologie<ins class="diffchange diffchange-inline">]] </ins></div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline">[[category:Endokrinologie</ins>]]</div></td></tr> <!-- diff generator: internal 2026-05-05 15:41:57 --> </table>

Kulan http://www.kulan.cz/index.php?title=Dyslipidemie&diff=9222&oldid=prev 2023-10-26T21:04:32Z

<p><span class="autocomment">STATINY</span></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr valign='top'> <td colspan='2' style="background-color: white; color:black;">← Starší verze</td> <td colspan='2' style="background-color: white; color:black;">Verze z 26. 10. 2023, 21:04</td> </tr> <tr><td colspan="2" class="diff-lineno">Řádka 218:</td> <td colspan="2" class="diff-lineno">Řádka 218:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>KI: těhotenství, laktace, jaterní insuficience</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>KI: těhotenství, laktace, jaterní insuficience</div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"></ins></div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">Užívání 1x denně. U starších preparátů (simvastatin, lovastatin, fluvastatin) s kratším poločasem vhodnější užívání večer, kdy více působí na endogenní noční syntézu chosterolu </ins></div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"></ins></div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">novější (atorvastatin, rosuvastatin, pravastatin) je působení 24hodinové, mohou se užívat v kteroukoliv dobu, ranní užívání mívá lepší compliance s léčbou</ins></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>=== '''INHIBICE VSTŘEBÁVÁNÍ CHOLESTEROLU'''===</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>=== '''INHIBICE VSTŘEBÁVÁNÍ CHOLESTEROLU'''===</div></td></tr> <!-- diff generator: internal 2026-05-05 15:41:57 --> </table>

Kulan http://www.kulan.cz/index.php?title=Dyslipidemie&diff=9145&oldid=prev 2023-09-15T19:04:22Z

<p><span class="autocomment">Metabolismus lipidů</span></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr valign='top'> <td colspan='2' style="background-color: white; color:black;">← Starší verze</td> <td colspan='2' style="background-color: white; color:black;">Verze z 15. 9. 2023, 19:04</td> </tr> <tr><td colspan="2" class="diff-lineno">Řádka 87:</td> <td colspan="2" class="diff-lineno">Řádka 87:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>aterogenní index = celkový cholesterol/HDL</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>aterogenní index = celkový cholesterol/HDL</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>cholesterol - hladina se mění až po 1 - 2 měsících (poločas 1 - 2 měsíce)</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>cholesterol - hladina se mění až po 1 - 2 měsících (poločas 1 - 2 měsíce) &nbsp;</div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>&#160;</div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>&#160;</div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline">'''Lp(a)''' - geneticky daný, nezávislý sna stravě</ins></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Dyslipoproteinemie ==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Dyslipoproteinemie ==</div></td></tr> <!-- diff generator: internal 2026-05-05 15:41:57 --> </table>

Kulan http://www.kulan.cz/index.php?title=Dyslipidemie&diff=9144&oldid=prev 2023-09-15T19:03:16Z

<p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr valign='top'> <td colspan='2' style="background-color: white; color:black;">← Starší verze</td> <td colspan='2' style="background-color: white; color:black;">Verze z 15. 9. 2023, 19:03</td> </tr> <tr><td colspan="2" class="diff-lineno">Řádka 35:</td> <td colspan="2" class="diff-lineno">Řádka 35:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>snížení LDL-cholesterolu o 1% vede k 1% snížení kardiovaskulárních příhod</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>snížení LDL-cholesterolu o 1% vede k 1% snížení kardiovaskulárních příhod</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"></ins></div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">již tabluky SCORE 2</ins></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Metabolismus lipidů ==</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>== Metabolismus lipidů ==</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>'''Chylomikrony''' &nbsp;</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>'''Chylomikrony''' &nbsp;</div></td></tr> <tr><td colspan="2" class="diff-lineno">Řádka 281:</td> <td colspan="2" class="diff-lineno">Řádka 283:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>úprava dávkování dle tíže renální insuficience, vhodné monitorovat jaterní testy (á 3 měsíce) + INR</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>úprava dávkování dle tíže renální insuficience, vhodné monitorovat jaterní testy (á 3 měsíce) + INR</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">může zmírnit projevy NPRD </ins></div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"></ins></div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"></ins></div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">=== Kyselina bempedová === </ins></div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">snižuje syntézu cholesterolu, což vede ke zvýšené expresi LDL-receptorů, což snižuje LKL v krvi </ins></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">a tím snižuje KV riziko, nemá svalové NÚ</ins></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[[category:Kardiologie]] &nbsp;</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[[category:Kardiologie]] &nbsp;</div></td></tr> <!-- diff generator: internal 2026-05-05 15:41:57 --> </table>

Kulan http://www.kulan.cz/index.php?title=Dyslipidemie&diff=9032&oldid=prev 2022-07-31T18:29:15Z

<p><span class="autocomment">STATINY</span></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr valign='top'> <td colspan='2' style="background-color: white; color:black;">← Starší verze</td> <td colspan='2' style="background-color: white; color:black;">Verze z 31. 7. 2022, 18:29</td> </tr> <tr><td colspan="2" class="diff-lineno">Řádka 205:</td> <td colspan="2" class="diff-lineno">Řádka 205:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>'''rosuvastatin''' nejúčinnější, ale nejdražší (nejúčinější + není metabolizován CYP - nejmenší riziko interakcí)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>'''rosuvastatin''' nejúčinnější, ale nejdražší (nejúčinější + není metabolizován CYP - nejmenší riziko interakcí)</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>'''fluvastatin''' - (''Lescol XL'') extra dobře snášenlivý, používá se u transplantovaných <del class="diffchange diffchange-inline">- není už na trhu</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>'''fluvastatin''' - (''Lescol XL'') extra dobře snášenlivý, používá se u transplantovaných &nbsp;</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>NÚ - vzácné</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>NÚ - vzácné</div></td></tr> <!-- diff generator: internal 2026-05-05 15:41:57 --> </table>

Kulan http://www.kulan.cz/index.php?title=Dyslipidemie&diff=9009&oldid=prev 2021-12-19T20:08:56Z

<p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr valign='top'> <td colspan='2' style="background-color: white; color:black;">← Starší verze</td> <td colspan='2' style="background-color: white; color:black;">Verze z 19. 12. 2021, 20:08</td> </tr> <tr><td colspan="2" class="diff-lineno">Řádka 1:</td> <td colspan="2" class="diff-lineno">Řádka 1:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Cílové hodnoty LDL-cholesterolu: &nbsp;</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Cílové hodnoty LDL-cholesterolu: &nbsp;</div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"></ins></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>nízké kardiovaskulární riziko &lt; 3,8 mmol/l</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>nízké kardiovaskulární riziko &lt; 3,8 mmol/l</div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">* týká se pacientů se SCORE &lt;1 %</ins></div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"></ins></div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">střední KV riziko </ins></div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">* SCORE 1-5 % </ins></div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">* DM2 pod 50 let věku </ins></div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">* DM1 pod 30 let věku </ins></div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">* DM trvající méně než 10 let</ins></div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"></ins></div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"></ins></div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">vysoké KV riziko &lt; 1,8 mmol/l</ins></div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">* SCORE 5-10 % </ins></div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">* celkový cholesterol &gt; 8 mmol/l </ins></div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">* familiární hypercholesterolemei </ins></div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">* hypertenze s TK &gt; 180/110 mmHg</ins></div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">* DM bez orgánového postižení trvající déle než 10 let </ins></div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">* CKD 3. stupně</ins></div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"></ins></div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">velmi vysoké KV riziko &lt; 1,4 mmol/l</ins></div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">* SCORE nad 10% </ins></div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">* aterosklerotické KVO </ins></div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">* DM s orgánovými komplikacemi </ins></div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">* CKD 4 a více</ins></div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"></ins></div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">extrémní KV riziko &lt;1,0 mmol/l</ins></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del class="diffchange diffchange-inline">vysoké KV riziko &lt; 3</del>,<del class="diffchange diffchange-inline">3 mmol/l</del></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline">při LDL &gt;4</ins>,<ins class="diffchange diffchange-inline">9 zahájit farmakologickou intervenci vždy</ins></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del class="diffchange diffchange-inline">velmi vysoké KV riziko &lt; </del>2,6 mmol/l</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline">všichni DM mají mít cíl nejvýše </ins>2,6 mmol/l</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <!-- diff generator: internal 2026-05-05 15:41:57 --> </table>

Kulan http://www.kulan.cz/index.php?title=Dyslipidemie&diff=9008&oldid=prev 2021-12-19T19:54:29Z

<p><span class="autocomment">Terapie dyslipidemií</span></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr valign='top'> <td colspan='2' style="background-color: white; color:black;">← Starší verze</td> <td colspan='2' style="background-color: white; color:black;">Verze z 19. 12. 2021, 19:54</td> </tr> <tr><td colspan="2" class="diff-lineno">Řádka 153:</td> <td colspan="2" class="diff-lineno">Řádka 153:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>* monitorace jaterních testů a CK (na začátku a při obtížích), při CK nad trojnásobek léčbu ukončit</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>* monitorace jaterních testů a CK (na začátku a při obtížích), při CK nad trojnásobek léčbu ukončit</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"></ins></div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">Niacin (kys. nikotinová) - časté a nepříjemné NÚ: svědění, dyspepsie, hepatotoxicita, již se nedoporučuje užívat</ins></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>=== '''STATINY''' ===</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>=== '''STATINY''' ===</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>'''inhibice HMG-CoA reduktázy''' (z HMG-CoA na mevalonát) &nbsp;</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>'''inhibice HMG-CoA reduktázy''' (z HMG-CoA na mevalonát) &nbsp;</div></td></tr> <tr><td colspan="2" class="diff-lineno">Řádka 254:</td> <td colspan="2" class="diff-lineno">Řádka 256:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>úprava dávkování dle tíže renální insuficience, vhodné monitorovat jaterní testy (á 3 měsíce) + INR</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>úprava dávkování dle tíže renální insuficience, vhodné monitorovat jaterní testy (á 3 měsíce) + INR</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del style="color: red; font-weight: bold; text-decoration: none;">=== NIACIN - kys nikotinová ===</del></div></td><td colspan="2">&nbsp;</td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del style="color: red; font-weight: bold; text-decoration: none;">* snížení syntézy VLDL v játrech a tím i LDL</del></div></td><td colspan="2">&nbsp;</td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del style="color: red; font-weight: bold; text-decoration: none;">* zvyšuje hladinu HDL, snižuje TAG</del></div></td><td colspan="2">&nbsp;</td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del style="color: red; font-weight: bold; text-decoration: none;">* snižuje hladiny lipoproteinu(a)</del></div></td><td colspan="2">&nbsp;</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del style="color: red; font-weight: bold; text-decoration: none;">časté a nepříjemné NÚ: svědění, dyspepsie, hepatotoxicita</del></div></td><td colspan="2">&nbsp;</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del style="color: red; font-weight: bold; text-decoration: none;">již se nedoporučuje užívat</del></div></td><td colspan="2">&nbsp;</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[[category:Kardiologie]] &nbsp;</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[[category:Kardiologie]] &nbsp;</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[[category:Metabolismus]]</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[[category:Metabolismus]]</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[[category:Farmakologie]]</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[[category:Farmakologie]]</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[[category:Gastroenterologie]]</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>[[category:Gastroenterologie]]</div></td></tr> <!-- diff generator: internal 2026-05-05 15:41:57 --> </table>

Kulan http://www.kulan.cz/index.php?title=Dyslipidemie&diff=9004&oldid=prev 2021-12-10T06:53:05Z

<p></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr valign='top'> <td colspan='2' style="background-color: white; color:black;">← Starší verze</td> <td colspan='2' style="background-color: white; color:black;">Verze z 10. 12. 2021, 06:53</td> </tr> <tr><td colspan="2" class="diff-lineno">Řádka 1:</td> <td colspan="2" class="diff-lineno">Řádka 1:</td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">Cílové hodnoty LDL-cholesterolu: </ins></div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"></ins></div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">nízké kardiovaskulární riziko &lt; 3,8 mmol/l</ins></div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"></ins></div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">vysoké KV riziko &lt; 3,3 mmol/l</ins></div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"></ins></div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">velmi vysoké KV riziko &lt; 2,6 mmol/l</ins></div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"></ins></div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"></ins></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>snížení LDL-cholesterolu o 1% vede k 1% snížení kardiovaskulárních příhod</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>snížení LDL-cholesterolu o 1% vede k 1% snížení kardiovaskulárních příhod</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <!-- diff generator: internal 2026-05-05 15:41:57 --> </table>

Kulan http://www.kulan.cz/index.php?title=Dyslipidemie&diff=9002&oldid=prev 2021-10-26T16:11:08Z

<p><span class="autocomment">STATINY</span></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr valign='top'> <td colspan='2' style="background-color: white; color:black;">← Starší verze</td> <td colspan='2' style="background-color: white; color:black;">Verze z 26. 10. 2021, 16:11</td> </tr> <tr><td colspan="2" class="diff-lineno">Řádka 169:</td> <td colspan="2" class="diff-lineno">Řádka 169:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>'''rosuvastatin''' nejúčinnější, ale nejdražší (nejúčinější + není metabolizován CYP - nejmenší riziko interakcí)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>'''rosuvastatin''' nejúčinnější, ale nejdražší (nejúčinější + není metabolizován CYP - nejmenší riziko interakcí)</div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>'''fluvastatin''' - extra dobře snášenlivý, používá se u transplantovaných</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>'''fluvastatin''' - <ins class="diffchange diffchange-inline">(''Lescol XL'') </ins>extra dobře snášenlivý, používá se u transplantovaných <ins class="diffchange diffchange-inline">- není už na trhu</ins></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>NÚ - vzácné</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>NÚ - vzácné</div></td></tr> <!-- diff generator: internal 2026-05-05 15:41:57 --> </table>

Kulan http://www.kulan.cz/index.php?title=Dyslipidemie&diff=8841&oldid=prev 2018-06-13T20:33:44Z

<p><span class="autocomment">Terapie dyslipidemií</span></p> <table style="background-color: white; color:black;"> <col class='diff-marker' /> <col class='diff-content' /> <col class='diff-marker' /> <col class='diff-content' /> <tr valign='top'> <td colspan='2' style="background-color: white; color:black;">← Starší verze</td> <td colspan='2' style="background-color: white; color:black;">Verze z 13. 6. 2018, 20:33</td> </tr> <tr><td colspan="2" class="diff-lineno">Řádka 192:</td> <td colspan="2" class="diff-lineno">Řádka 192:</td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>vstřebává se do krve, nezpůsobuje průjmy (na rozdíl od pryskyřic)</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>vstřebává se do krve, nezpůsobuje průjmy (na rozdíl od pryskyřic)</div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;"></ins></div></td></tr> <tr><td colspan="2">&nbsp;</td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins style="color: red; font-weight: bold; text-decoration: none;">''Indikační omezení úhrady dle SÚKL: u nemocných, u kterých nelze dosáhnout cílových hodnot LDL (3 mmol/l u obecné populace, 2,5mmol/l u osob s manifestací ateroskledrózy či diabetem) pomocí 20mg atorvastatinu/den, 40mg simvastatinu/den, nebo 20mg rosuvastatinu/den, nebo kdy tyto statiny nelze použít (např. pro intoleranci, riziko interací apod.)''</ins></div></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr> <!-- diff generator: internal 2026-05-05 15:41:57 --> </table>

Kulan